Geriatric Psychiatry • August 22, 2026
Healthy Aging and Neurodegeneration: Psilocybin in Geriatric Psychiatry
Emerging pilot trials evaluate microdoses of psilocybin for Mild Cognitive Impairment (MCI), stimulating synaptogenesis and protecting aging memory circuits.
Synaptic Decay in Mild Cognitive Impairment (MCI)
Early neurodegenerative decline is characterized by progressive loss of dendritic spines in the entorhinal cortex and hippocampus.
Microdosing as a Regenerative Therapy for Seniors
By elevating BDNF and enhancing cerebral blood flow without causing disorientation, sub-perceptual microdosing offers a promising novel neuroprotective strategy.