OCD Research • October 04, 2026
Obsessive-Compulsive Disorder (OCD): Disrupting Cortico-Striato-Thalamo-Cortical (CSTC) Loops
Clinical studies demonstrate that psilocybin breaks hyper-connected CSTC loops responsible for obsessive thoughts and compulsive checking behaviors.
The CSTC Circuit In OCD Pathophysiology
OCD is driven by persistent, hyper-synchronous reverberation in the cortico-striato-thalamo-cortical (CSTC) pathway, locking sufferers into unrelenting compulsion loops.
Rapid Reduction in Y-BOCS Symptom Scores
In a landmark trial at the University of Arizona, patients treated with psilocybin experienced significant immediate drops in Yale-Brown Obsessive Compulsive Scale (Y-BOCS) scores.