Neurology • October 06, 2026
Cluster Headaches and Migraine Prophylaxis: Psilocybin and Trigeminal Vascular Modulation
Yale Clinical Trials reveal that 2 to 3 low doses of psilocybin produce weeks-to-months of complete remission from refractory cluster headache cycles.
The Agony of Cluster Headaches ("Suicide Headaches")
Cluster headache is one of the most painful neurological conditions known, causing excruciating unilateral orbital pain that recurs in debilitating multi-week cycles.
Yale School of Medicine Clinical Breakthrough
In clinical research conducted at Yale University, a brief pulse protocol of sub-psychedelic or low-dose psilocybin reduced headache frequency by over 50% compared to baseline, terminating ongoing cluster cycles.
Hypothalamic and Trigeminal Vascular Mechanism
Psilocin exerts potent vasoconstrictive and anti-inflammatory action on cranial blood vessels via 5-HT1D and 5-HT2A receptors while resetting central hypothalamic circadian pacemakers.